As with all prescription medicines, the patient should not allow anyone else to use his medicine. The recommended frequency of injection is no more than 3 times weekly, with at least 24 hours between each dose. 17. The reconstituted edex® cartridge and needle are intended for single use only and should be discarded after use. There was no evidence of significant accumulation of radiolabeled α-cyclodextrin in the body even after 7 days of repeated intravenous injection. If bleeding continues or recurs after applying pressure, abstain from intercourse. The 6 Pack contains the following items: Six single-dose, dual-chamber cartridges (one per injection), Six ½-inch, 29-gauge (0.33 mm x 12.7 mm) sterile needles (one per injection). edex … If your partner experiences insufficient vaginal lubrication or painful vaginal sensations during intercourse, the use of a lubricant may be helpful. Prolonged erections greater than four hours in duration occurred in 4% of all patients treated up to 24 months. Your dose has been customized for your individual needs. Careful instruction in proper patient handling and injection techniques may minimize the potential for needle breakage. After reconstitution, the active ingredient, alprostadil, immediately dissociates from the α-cyclodextrin inclusion complex. The plunger is used to force the sterile 0.9% sodium chloride (1.075 mL) in one chamber into the chamber containing alprostadil. Papaverine plus phentolamine plus Alprostadil (Trimix) is the most potent but ... physical status, whether the proper dosage was properly injected and the presence of In two studies with a dose range of 1 to 40 mcg of edex® (alprostadil for injection) , the mean dose was 21.9 mcg at the end of the dose titration period. Learn more about Alprostadil (Muse) at EverydayHealth.com. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Note: Always attach the needle to the injection device before inserting the cartridge into the injection device. Unscrew the blue portion of the plunger from the injection device. In two studies with a dose range of 1 to 40 mcg of edex®, the mean dose was 21.9 mcg at the end of the dose titration period. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If you cannot see or cannot grasp the broken end, you should promptly contact your doctor. Buy Edex (Alprostadil) Description: Edex (Alprostadil) is a prostaglandin (PGE-1) used to treat impotence. A normal cake may appear cracked or crumbled. Use only the dose prescribed by your doctor. I would be careful as to the dose that is used. edex® Cartridge 2 Pack contains one reusable edex® injection device, two single-dose, dual-chamber cartridges, two ½ inch, 29 gauge (0.33 mm x 12.7 mm) needles, and four alcohol swabs. This document should also be useful to those considering the use of injection … A ½ inch, 27 to 30 gauge needle is generally recommended for the intracavernous injection. penile bypass or implants), hormone treatment, psychological counseling, lifestyle changes, or a change in medication. The binding of alprostadil to its receptors is accompanied by an increase in intracellular cAMP levels. After reconstitution, PGE1 immediately dissociates from the α-cyclodextrin inclusion complex; the in vivo disposition of both components occurs independently after administration. The human dose of edex® is <1 mcg/kg (MRHD is 40 mcg and the calculation assumes a 60-kg subject). Tell your doctor if you have a condition or are taking a medicine that interferes with blood clotting. After intracavernous administration in monkeys, radiolabeled α-cyclodextrin was rapidly distributed from the injection site with less than 0.1% of the dose remaining in the penis 1 hour after administration. A convenient carrying case is provided for the reusable edex® injection device. The mechanism responsible for the observed discrepancies between renally impaired subjects and healthy volunteers is not known. Do not use more than 2 pellets in one day. The reconstituted solution should be gently mixed, not shaken. The primary symptom of an edex® overdose is a prolonged erection or priapism. See patient information for edex®. PGE1 is metabolized in the corpus cavernosum after intracavernous administration. Pain at the injection site hematoma, caverns, fibrous assemblies, plaque, penile deviation. 4. The reconstituted solution should not be stored. The reconstituted drug solution should be used immediately after reconstitution. 18. The mean optimum dose was 13.8 mcg (range 1 to 20 mcg). 4) After injection of the edex® solution, compression of the injection site for five minutes, or until bleeding stops, is necessary. The empirical formula is C20H34O5 and the molecular weight is 354.49. Discard your needle in a special container for disposal of sharp medical supplies. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Interaction CAUTION: Do not reuse any solution remaining in the cartridge due to the possibility of bacterial contamination. dosage edex 10 edex injection youtube much does edex cost From there, an experienced real estate agent can guide them through the process with the help of a professional mortgage broker or bank. After intravenous infusion of radiolabeled α-cyclodextrin to healthy volunteers, the radiolabeled components were rapidly eliminated within 24-hours, urine accounting for 81% to 83% of radioactivity and feces for 0.1%. Call your doctor if you notice any redness, lumps, swelling, tenderness or curvature of the erect penis. The absolute bioavailability of alprostadil estimated from systemic exposure was about 98% as compared to the same dose given by a short-term intravenous infusion. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Attach the needle to the tip of the Edex injection device. To minimize the chances of prolonged erection or priapism, edex® should be titrated slowly to the lowest effective dose (see DOSAGE AND ADMINISTRATION). Hypotension occurred in less than 1% of patients treated with edex®. The edex® cartridges contain a solid layer or cake of dry white powder approximately 3/8” in thickness. The edex® injection device is used to reconstitute the single-dose, dual-chamber cartridge. Alprostadil had a significant effect on the pharmacodynamics of heparin resulting in a 140% increase in partial thromboplastin time and a 120% increase in thrombin time. If you have any questions after reading the instructions, talk to your doctor. what does edexcel linear mean I use 3 amps, but many times just use one depending on the venue, etc. Thereafter, patients continued to perform self-injections of open-label edex® for six or 12 months, and the occurrence of an erection sufficient for sexual intercourse was documented following each injection. There were no clinically important changes or trends in pharmacodynamic parameters for these drugs. These drugs increase blood flow by expanding blood vessels. During the subsequent two-week double-blind, cross-over phase, patients self-injected edex® or placebo at home. It may also be used to diagnose impotence. Long-term carcinogenicity studies have not been conducted. Have a clean area available to assemble the items necessary for your edex ® injection. A standard treatment goal is to produce an erection lasting no longer than 1 hour. 5. edex availability. Avoid extremes in temperature. Smooth muscle relaxation is associated with a reduction of the cytoplasmic free calcium concentration. 5. The patient is advised not to exceed the optimum edex® dose which was determined in the doctor's office. If there is a partial response, the dose may be increased by 2.5 mcg to a dose of 5 mcg and then in increments of 5 to 10 mcg, depending upon erectile response, until the dose that produces an erection suitable for intercourse and not exceeding a duration of 1 hour is reached. Edex Injection Dosage and Administration. Beginning with a 40 mcg bolus intravenous dose, the frequency of drug-related systemic adverse events increased in a dose-dependent manner, characterized mainly by facial flushing. Make sure to inject at the base of the penis, and between 2 and 4 ‘o clock, or 8 to 10 ‘o clock positions in order not to damage the urethra or the nerves and blood vessels in the penis. After intracavernous injection of 20 mcg of edex® in 24 patients with erectile dysfunction, mean systemic plasma concentrations of PGE1 increased from baseline of 0.8 ± 0.6 pg/mL to a peak (Cmax) of 16.8 ± 18.9 pg/mL (corrected for baseline) within 2 to 5 minutes and dropped to endogenous plasma levels within 2 hours (Table 1). Edex Injection Dosage, erectile dysfunction after steroid facts, Free Samples Of Edex Injection Dosage Penis Enhancement, amazon penis pills, best natural alternative to viagra. The physician should instruct the patient to discard any needles which become bent during the self-injection procedure as these needles may break. Mix edex ® just prior to injection. Learn more about Edex ... A common side effect of Edex is mild to moderate pain during injection. 5) Underlying treatable medical causes of erectile dysfunction should be diagnosed and treated prior to initiation of therapy with edex®. The terminal half-life of PGE1 in healthy volunteers was calculated to be around 9 to 11 minutes which is consistent with that reported in the literature (8 minutes). You should not use edex® more than 3 times a week. The terminal half-lives of PGE1, PGE0, and 15-keto-PGE0 and plasma albumin levels were similar in these patients vs healthy volunteers. Self-Injection Procedure. Medically reviewed by Drugs.com. 3) The safety and efficacy of combinations of edex® and other vasoactive agents have not been systematically studied. In a study with a dose range of 1 to 20 mcg of edex®, the mean dose was 10.7 mcg at the end of the dose titration period. As with any drug product, extremes in temperature should be avoided. Initial 2.5 mcg intracavernosal injection. Ask your doctor or pharmacist where you can obtain these special containers. edex drug. 13. The pharmacokinetic and pharmacodynamic interaction between alprostadil intravenous infusion, 90 mcg over 3 hours, and heparin (5,000 IU) was evaluated in 12 healthy volunteers. Penile pain was judged by patients to be mild in intensity for 80% of painful injections, moderate in intensity for 16% of painful injections, and severe in intensity for 4% of painful injections. Each needle and cartridge should be used only once. After further degradation of PGE1 by beta and omega oxidation, the main metabolites are excreted primarily in urine (88%) and feces (12%) over 72 hours, and total excretion is essentially complete (92%) within 24 hours after administration. Choose an injection site mid-shaft on one side of the penis. A patient information pamphlet is included in each package of edex® cartridges. During the dose-titration phase, individualized optimum doses of edex® were established. Be sure to use only the dose prescribed by your doctor. Although the injection method is the same, the mixing procedures are different. Please read this information carefully before you prepare the edex® solution. The needle must be properly discarded after use; it must not be reused or shared with other persons. The overall incidence of penile fibrosis, including Peyronie's disease, reported in clinical studies up to 24 months with edex® was 7.8%. This leads to expansion of lacunar spaces and entrapment of blood by compressing the venules against the tunica albuginea, a process referred to as the corporal veno-occlusive mechanism. The dose of edex® that is established in the physician's office should not be changed by the patient without consulting the physician. Learn about uses, dosing and support offered for edex® (alprostadil for injection) for injection. The needle must be properly discarded after use; it must not be reused or shared with other persons. Please keep this information in case you need to refer to it again. (Also, see Drug-Drug Interactions in CLINICAL PHARMACOLOGY, Pharmacokinetics.). does edexcel send results to ucas. After reconstitution, the edex® injection device is used to administer the intracavernous injection of alprostadil. How was your experience with Edex? Insert the cartridge into the injection device with the tip facing toward the attached needle (Figure F). The injection site must be cleansed with an alcohol swab before injection. The edex® cartridge contains a solid layer or lyophilized cake of dry white powder approximately 3/8" in thickness. Edex Injection Dosage, zyflex price, Now You Can Buy Edex Injection Dosage For Sale Online, women arousal products, increase sexual appetite men. Sterile Powder and Diluent difference entre edex et caverject. The mean duration of erection following edex® was 59.0 minutes compared to 7.6 minutes following placebo. The injection site must be cleansed with an alcohol swab before injection. The chemical structure is: The α-cyclodextrin inclusion complex improves the water solubility of alprostadil. Visit cvs.com for more details. The reconstituted cartridge is designed for one use only and should be discarded after use. The reconstituted edex® cartridge and needle are intended for single use only and should be discarded after use. Withdraw needle from penis. The solution may initially appear cloudy due to small air bubbles. Discard any unused solution remaining in the cartridge. Limited data are available in regard to edex® overdose in humans. In placebo-controlled studies, the frequency of local bleeding was 6% with injection of edex® and 3% with injection of placebo. There are several causes of erectile dysfunction, commonly known as impotence. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Compare prices, print coupons and get savings tips for Edex and other Erectile Dysfunction drugs at CVS, Walgreens, and other pharmacies. Edex allergy in children. The patient must visit the physician's office for regular checkups for assessment of the therapeutic benefit and safety of treatment with edex®. Adult males. If there is no response to the initial 2.5-mcg dose, the second dose may be increased to 7.5 mcg, followed by increments of 5 to 10 mcg. There is a potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease. The reusable edex® injection device is for use only with the cartridges and needles included in the edex® Cartridge Packs. The intracavernous injection must be done under sterile conditions. Open the medication car-tridge packet. Your pharmacist may know of alternate uses for Edex … 1) Intracavernous injections of edex® can lead to increased peripheral blood levels of PGE1 and its metabolites, especially in those patients with significant corpora cavernosa venous leakage. Edex belongs to a group of drugs called vasodilators. This document was prepared to make the process as easy and painless as possible for men who have decided to use injection therapy for erectile dysfunction. Erectile Dysfunction: Causes and Treatments. Mean systemic plasma PGE0 levels increased within 20 minutes from endogenous levels of 0.6 ± 0.5 pg/mL to a Cmax of 3.9 ± 2.3 pg/mL (corrected for baseline) followed by a decrease to baseline levels in several hours. The edex® injection device is used to reconstitute the single-dose, dual-chamber cartridge. In a study in symptomatic subjects with end-stage renal disease undergoing hemodialysis and age/weight/sex-matched healthy volunteers, 120 mcg of alprostadil was administered by intravenous infusion over 2 hours. This occurs when you don’t put enough pressure on the injection site after removing the needle or from puncturing a skin vein. 4. Among the 60% (139/233) of patients who entered the open-label treatment phase, the mean rate of response with an erection sufficient for intercourse was 85.3% through six months. This is especially true for the initial self-injections, since adjustments in the dose of edex® may be needed. edex® is given as an intracavernous injection over a 5- to 10-second interval. Pregnancy, Nursing Mothers and Pediatric Use. Talk to your pharmacist for more details. The physician should make a careful assessment of the patient's skills and competence with the self-injection procedure. Medicine for edex allergy. 1. Do not use the cartridge if it appears damaged or the cake is substantially reduced in size. The pharmacodynamic interaction between heparin (5,000 units) and alprostadil intravenous infusion (90 mcg over 3 hours) was investigated. The user should be instructed in the proper disposal of the needles and cartridges. Mean Cmax values of both 15-keto-PGE0 and PGE0 increased 65% as compared to those in healthy volunteers. Hope this helps. One chamber of the cartridge contains 10.75, 21.5, or 43 mcg of alprostadil as a white, sterile, lyophilized powder. Visible veins should be avoided. Initial 2.5 mcg intracavernosal injection; Titrate by 2.5 mcg, THEN by 5-10 mcg intervals until erection of ; 1 hr maintained; not to exceed 40 mcg (Edex) or 60 mcg (Caverject); If no absolute response to 2.5 mcg dose, may increase second dose to 7.5 mcg followed by increments of 5-10 mcg When the cartridge is placed into the edex® injection device and reconstituted, the deliverable amount of alprostadil in each milliliter is 10, 20 or 40 micrograms, respectively. ‌ Read this resource carefully before starting injection therapy. Find answers to frequently asked questions and savings for patients. The patient must stay in the physician's office until complete detumescence occurs. Unlike the 15-keto metabolites which are less pharmacologically active than the parent compound, PGE0 is similar in potency to PGE1 in vitro using isolated animal organs. Accordingly, the patient should be instructed to contact the physician's office immediately or, if unavailable, to seek immediate medical assistance if an erection persists for longer than 6 hours. The side of the penis that is injected and the site of injection must be alternated. Alprostadil is an endogenous substance known as prostaglandin E1 (PGE1). A common side effect of edex® is mild to moderate pain during injection. As with all prescription medicines, the patient should not allow anyone else to use his medicine. I would be careful as to the dose that is used. The pharmacokinetic profiles of aspirin, warfarin, digoxin, and glyburide were not affected by concomitant administration of alprostadil. The edex. Alprostatil transurethral pellet is a very small suppository to be inserted into the opening of the penis (the urethra). This leaflet provides a summary of information about your medicine. The reconstituted solution may initially appear cloudy due to small air bubbles. Discontinuation of therapy due to a side effect in clinical trials was required in approximately 9% of patients treated with edex® and in <1% of patients treated with placebo. The edex® injection device is used to reconstitute the single-dose, dual-chamber cartridge. After intracavernous injection of 20 mcg of edex® to 24 patients with erectile dysfunction, mean systemic plasma 15-keto-PGE0 levels increased within 7 minutes from endogenous levels of 12.9 ± 11.8 pg/mL to a Cmax of 421 ± 337 pg/mL (corrected for baseline) followed by a decrease to baseline levels in several hours. After reconstitution, the edex® injection device is used to administer the intracavernous injection of alprostadil. 11. If the solution does not inject easily, or if you immediately experience a burning pain at the injection site, reposition the needle by advancing it slightly or by partially withdrawing it until the solution can be injected easily and painlessly. Please read carefully before using. The dosage range of edex ® for the treatment of erectile dysfunction is 1 to 40 mcg. Mean total body clearance of PGE1 in patients with erectile dysfunction was calculated to be around 115 L/min after an intravenous infusion of 20 mcg alprostadil. As with any injection, infection is possible. It is more expensive than trimix but you may just use it for this trip. After the world financial crisis, the international and Taiwan’s competitive landscape has completely changed. The edex® injection device is used to reconstitute the single-dose, dual-chamber cartridge. When the single-dose, dual-chamber cartridge containing either 10.75, 21.5, or 43 mcg of alprostadil is placed into the edex® injection device and reconstituted, the deliverable amount of alprostadil in each milliliter is 10, 20 or 40 mcg, respectively. Your pharmacist may know of alternate uses for Edex … It occurs most commonly with injectables containing papaverine. See patient information for edex®. The reconstituted drug solution should be used immediately after reconstitution. Carefully follow the instructions for administration which are described below. The incidence of priapism (erections greater than 6 hours in duration) was <1% with long-term use for up to 24 months. A potentially serious adverse reaction with intracavernous therapy is priapism. There is a possibility of needle breakage with use of edex®. 8)Cardiovascular Risk Related to Underlying Medical Conditions. Endo Pharmaceuticals Inc. Pharmacology, adverse reactions, warnings and side effects. Do not touch the exposed needle or allow the needle to touch anything. These work by relaxing the muscles and blood vessels in the penis so that an erection can occur. Available for Android and iOS devices. EdeX Technology Co., Ltd. was established in 2009. NOTE: edex® offers no protection from the transmission of sexually transmitted diseases such as HIV (the virus that causes AIDS). Treatment can be resumed if the penile abnormality subsides. 1. In patients treated with edex® for up to 24 months, local bleeding, hematoma, and ecchymosis were observed in 15%, 5%, and 4% of patients, respectively. 2. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The reusable edex® injection device is for use only with the cartridges and needles included in the edex® Cartridge Packs. Hemodynamic changes, manifested as increases or decreases in blood pressure and pulse rate, were observed during clinical studies but did not appear to be dose-dependent. This medication should usually work within 5 to 20 minutes to produce an erection that lasts for about 1 hour. Clinical Results The intracavernous injection should be given over a 5 to 10 second interval. The mean Cmax value of PGE1 in renally impaired patients was 37% lower as compared to that in healthy volunteers whereas mean Cmax values of 15-keto-PGE0 and PGE0 in these patients increased 104% and 145%, respectively, as compared to those in healthy volunteers. edex® Cartridge 2 Pack contains enough supplies for two injections. In a study with a dose range of 1 to 20 mcg of edex®, the mean dose was 10.7 mcg at the end of the dose titration period. The site of injection is usually along the lateral aspect of the proximal third of the penis. edex dosage. Careful and continuous follow-up of the patient while in the self-injection program must be exercised. Do not administer unless solution is clear. This medication should usually work within 5 to 20 minutes to produce an erection that lasts for about 1 hour. 21. The patient should be instructed not to reuse or to share needles or cartridges. EDEX is administered by intracavernous injection and was found to be a safe and effective treatment for impotence. Do not discard the large external protective cap; you will need to use it later. 20. Edex and Caverject cost an average of 1. If there is no response, then the next higher dose may be given within 1 hour. Do not add any drugs or solutions to the edex® solution. EDEX prescription and dosage sizes information for physicians and healthcare professionals. We comply with the HONcode standard for trustworthy health information -. Systemic reactions are uncommon with intracavernous injection of edex®. Drug Name Active Ingredients Strength Dosage Form/Route Marketing Status TE Code RLD RS; EDEX: ALPROSTADIL: 0.005MG/VIAL: INJECTABLE;INJECTION: Discontinued: None CAUTION: Do not reuse any solution remaining in the cartridge due to the possibility of bacterial contamination. (alprostadil for injection) Do not touch the tip of the cartridge after it has been cleansed with the alcohol swab (Figure E). edex® is injected into a specific area of the penis (see injection directions below) and should produce an erection in 5 to 20 minutes. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. edex user reviews. Due to the fact that PGE1 is primarily metabolized in the lung, the observed differences between hepatically impaired subjects and healthy volunteers were not anticipated; the mechanism responsible for the observed discrepancies is not known. The erection may also be associated with a painful sensation. Small amounts of bleeding at the injection site can increase the risk of transmission of blood-borne diseases between partners. The terminal half-lives of PGE1, PGE0, and 15-keto-PGE0 and plasma albumin levels were similar in patients compared to healthy volunteers. If you don’t follow the instructions in this resource, your doctor or APP may stop prescribing your penile injection medications and supplies. Remove the seal from the base of the needle. The above value exceeded cardiac output indicating extensive and rapid elimination of PGE1 in the lungs and/or blood. Men who have conditions that might result in long-lasting erections should not use edex®. May give 2 nd dose of 2.5mcg, and 3 rd dose of 5mcg, and then may increase by increments of 5mcg until desired response achieved. Prepare the edex® solution immediately before use. Although the injection method is the same, the mixing procedures are different. Wash your hands thoroughly with soap and water and dry them with a clean towel. If there is a response, then there should be at least a 1-day interval before the next dose is given. 8. Pharmacologic intervention and/or aspiration of blood from the corpora was necessary in 1.6% of 311 patients with prolonged erections/priapism. A single dose rising tolerance study in healthy volunteers indicated that single intravenous doses of alprostadil from 1 to 120 mcg were well tolerated. Erectile Dysfunction of Pure Neurogenic Etiology (Spinal Cord Injury): Dosage titration should be initiated at 1.25 mcg of alprostadil. Alprostadil or Prostaglandin E1 that does not require refrigeration is available as Edex or Caverject injections. To prevent bruising, apply firm pressure to the injection site for 5 minutes. The dosage range of edex® for the treatment of erectile dysfunction is 1 to 40 mcg. Careful and continuous follow-up of the patient while in the self-injection program must be exercised. edex® should be used no more than 3 times per week, with at least 24 hours between each use. 7. I think Wang Yafang edex injection will see it every day and night, but I should tell you why it is called Han, Hancock Building average dose of viagra One Han Hancock was a leader of Boston s overthrow of British rule.. Overall differences in safety were not observed between these geriatric patients and younger patients. injection edex. In addition, there are no data on the efficacy and safety of these combinations. Drug Information on Caverject, Caverject Impulse, Edex (alprostadil (injectable and transurethral)) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. There was no evidence of tissue retention of radiolabeled α-cyclodextrin in monkeys. Alprostadil showed no evidence of mutagenicity in three in vitro assays including the AMES bacterial reverse mutation assay, a forward gene mutation assay in Chinese hamster lung (V79) cells, and a chromosome aberration assay in human peripheral lymphocytes. The high dose of 200 mcg/kg/day is about 300 times the maximum recommended human dose (MRHD) on a body weight basis. The patient should follow the instructions in the patient information pamphlet to limit the possibility of bacterial contamination. Safely discard the supplies (see the “Discard Injection Supplies” section of these instructions). No unchanged PGE1 has been found in the urine and there is no evidence of tissue retention of PGE1 and its metabolites. 3 months), is strongly recommended to identify any penile changes. 4. In patients infected with blood-borne diseases, this could increase the risk of transmission of blood-borne diseases between partners. Rarely - hypotension, dizziness. Check to see if the seal on the base of the needle is intact. The pulmonary extraction of alprostadil following intravascular administration was reduced by 15% (66 ± 3.6% vs 78 ± 2.3%) in patients with acute respiratory distress syndrome (ARDS) compared with a group of patients with normal respiratory function who were undergoing cardiopulmonary bypass surgery. Side effects. These drugs increase blood flow by expanding blood vessels. The plunger is used to force the sterile 0.9% sodium chloride (1.075 mL) in one chamber into the chamber containing alprostadil.